Based on the Resolution of the Central Committee of the CPSU and the Council of Ministers of the USSR of September 26, 1987 No. 1088 "On the Ural and Far Eastern Branches of the USSR Academy of Sciences", the Resolution of the Presidium of the USSR Academy of Sciences of January 22, 1988 No. 12 and the Resolution of the Presidium of the Ural Branch of the USSR Academy of Sciences of February 1, 1988, Perm Scientific Center of the Ural Branch of the USSR Academy of Sciences was founded on the basis of institutions of the USSR Academy of Sciences located in the city of Perm.

The first chairman of Perm Scientific Center of the Ural Branch of the Russian Academy of Sciences (1988-2000) was Klyachkin Yury Stepanovich, Doctor of Technical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences.

From 2000 to 2017 Academician of the Russian Academy of Sciences Matveyenko Valery Pavlovich was Chairman of Perm Scientific Center of the Ural Branch of the Russian Academy of Sciences (on the basis of the Order of the Ural Branch of the Russian Academy of Sciences No. 108 from 15 June 2000).

In accordance with the Decree No. 274 of the Presidium of the Russian Academy of Sciences from 18 December 2007, the institution was renamed Perm Scientific Center of the Ural Branch of the Russian Academy of Sciences.

By the Decree of the Presidium of the Russian Academy of Sciences of December 13, 2011 No. 262, the type and name of Perm Scientific Center of the Ural Branch of the Russian Academy of Sciences was changed to the Federal State Budgetary Institution of Science.

In accordance with the Federal Law from 27 September 2013 No. 253-FE “On the Russian Academy of Sciences, the reorganization of state academies of sciences and the amendment of certain legislative acts of the Russian Federation” and the Decree of the Government of the Russian Federation of December 30, 2013 No. 2591-r, the PSC UB RAS was transferred to the jurisdiction of the Federal Agency for Scientific Organizations (FASO of Russia).

The Federal State Budgetary Institution of Science Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences (PFRC UB RAS) is organized in accordance with the order of FASO Russia N340 dated 26 June 2016, based on Perm Scientific Center of the Ural Branch of the Russian Academy of Sciences (PSC UB RAS) as a result of reorganization in the form of joining to it the Institute of Continuous Media Mechanics of the Ural Branch of the Russian Academy of Sciences (ICMM, Ural Branch of the Russian Academy of Sciences), the Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences and Sciences (ITC UB RAS), the Mining Institute of the Ural Branch of the Russian Academy of Sciences (MI UB RAS), the Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences (IEGM UB RAS), Perm Research Institute of Agriculture (PRIA).

From 2017 to 2022, the Director of the PFRC UB RAS was Academician of the Russian Academy of Sciences Alexander Abramovich Baryakh (based on the order of the FANO of Russia No. 688 of July 24, 2017). The Scientific Director was Academician of the Russian Academy of Sciences Valery Pavlovich Matveenko (based on the Resolution of the Presidium of the Russian Academy of Sciences No. 151 of September 19, 2017).

Since 2018, PFIC URO RAS has been subordinated to the Ministry of Science and Higher Education of the Russian Federation due to the abolition of FANO of Russia.

Oleg Anatolyevich Plekhov, Corresponding Member of the Russian Academy of Sciences, Doctor of Physical and Mathematical Sciences has been appointed the Director of the PFRC UB RAS since November 22, 2022 (based on the Order of the Ministry of Education and Science of Russia No. 10-3/280p-o dated November 18, 2022).

Valery Pavlovich Matveenko, Academician of the Russian Academy of Sciences, Doctor of Technical Sciences, Professor has been appointed the Scientific Director of the Center (based on the Resolution of the Presidium of the Russian Academy of Sciences No. 251 of November 2, 2022).

Alexander Abramovich Baryakh, Academician of the Russian Academy of Sciences, Doctor of Technical Sciences, Professor has been appointed the Head of the "Mining Sciences" direction of the Center (based on the Resolution of the Presidium of the Russian Academy of Sciences No. 252 of November 2, 2022).